This comprehensive roundtable discussion is developed to empower practicing clinicians with the most up-to-date clinical evidence surrounding the utilization of Extracorporeal Membrane Oxygenation (ECMO) in the treatment of COVID-19 patients. By the end of this course, participants will know how to navigate the unique cardiopulmonary and coagulation-related challenges presented by COVID-19, informed by the latest research findings and landmark studies. This course will also provide insights into the evolving clinical landscape related to ECMO application in COVID-19, guiding clinicians in shaping effective protocols for its use. Attendees will gain the expertise required to develop evidence-based strategies for managing ECMO-associated complications in COVID-19 patients, ensuring improved patient outcomes and enhanced clinical practice.