This handbook offers physicians and clinicians a comprehensive overview of the key components required to implement post-dilution high-volume hemodiafiltration (Hv-HDF). It includes 10 chapters that cover the evolution of dialysis modalities—particularly the progression from conventional hemodialysis (HD) to Hv-HDF—the mechanisms of hemodiafiltration (HDF), clinical evidence supporting its benefits, health economics and sustainability, practical guidance on implementation, strategies for patient selection, and considerations for medication management in patients undergoing HDF.