{"id":1240,"date":"2020-03-26T04:44:29","date_gmt":"2020-03-26T04:44:29","guid":{"rendered":"https:\/\/staging.advancedrenaleducation.com\/wparep\/?post_type=article&#038;p=1240"},"modified":"2025-05-09T16:12:35","modified_gmt":"2025-05-09T21:12:35","slug":"metabolic-alkalosis","status":"publish","type":"article","link":"https:\/\/staging.advancedrenaleducation.com\/wparep\/article\/metabolic-alkalosis\/","title":{"rendered":"Metabolic Alkalosis"},"content":{"rendered":"<ul>\n<li>The most common cause is the loss of hydrochloric acid as a result of vomiting or nasogastric suction<sup>1<\/sup><\/li>\n<li>Less common causes:\n<ul>\n<li>Technical errors during HD<\/li>\n<li>Malfunction of the dialysis machine\u2019s pH monitor and proportioning system (the reversed connection of bicarbonate and acid concentrate containers to the entry ports<sup>2<\/sup>)<\/li>\n<\/ul>\n<\/li>\n<li>Severe metabolic alkalosis may cause:\n<ul>\n<li>Tissue hypoxia<\/li>\n<li>Arrhythmia<\/li>\n<li>Seizure<\/li>\n<li>Delirium<\/li>\n<li>Stupor<\/li>\n<\/ul>\n<\/li>\n<li>Applying HD therapy with specially formulated low-bicarbonate, low-acetate, or acid dialyses are safe and effective intervention for severe metabolic alkalosis<sup>3<\/sup>.\u00a0 Severe metabolic alkalosis can be corrected rapidly and safely with bicarbonate concentrates dialysate between 25-28 mEq\/L<sup>4<\/sup>.<\/li>\n<\/ul>\n<div class=\"vcex-spacing\" style=\"height:30px\"><\/div><div class=\"vcex-module vcex-divider vcex-divider-solid\" style=\"width:100%;margin-top:20px;margin-bottom:20px;border-top-width:1px;border-color:#dddddd;\"><\/div>\n<h4>References:<\/h4>\n<ol>\n<li>Gennari FJ, Rimmer JM. Acid-base disorders in end-stage renal disease: Part II. <em>Semin Dial<\/em>\u00a03:161-165, 1990<\/li>\n<li>Sethi D, Curtis JR, Topham DL, Gower PE. Acute metabolic alkalosis during haemodialysis. <em>Nephron <\/em>51:119-120, 1989<\/li>\n<li>Leblanc M, Farah A. Severe metabolic alkalosis corrected by hemodialysis. <em>Clin Nephrol<\/em>\u00a048:65, 1997<\/li>\n<li>Hsu SC, Wang MC, Liu HL, Tsai MC, Huang JJ. Extreme metabolic alkalosis treated with normal bicarbonate hemodialysis. <em>Am J Kidney Dis<\/em> 37:E31, 2007<\/li>\n<\/ol>\n<div class=\"vcex-spacing\" style=\"height:30px\"><\/div>\n","protected":false},"featured_media":0,"template":"","format":"standard","meta":{"_acf_changed":false},"categories":[5],"tags":[60],"language":[41],"articles":[268],"class_list":["post-1240","article","type-article","status-publish","format-standard","hentry","category-articles","tag-intradialytic","language-english","articles-hemodialysis","entry","no-media"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Metabolic Alkalosis - Advanced Renal Education Program<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staging.advancedrenaleducation.com\/wparep\/article\/metabolic-alkalosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metabolic Alkalosis - 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